British Studies: the sterile environment that prevents infection can make babies more vulnerable to leukemia.
The cause of children’s acute leukemia (ALL) is often discussed long ago, and the London Cancer Institute (ICR) biologist, Mel Greaves, collected evidence from several decades of related research that the cancer is likely to be closely related to genetic mutations and childhood lack of infection.
Greaves is an internationally known cancer biologist, famous for its research on childhood leukemia and cancer evolution. In the past, it had been awarded the Royal Society (Royal Society) Royal medal, and Chris Bunce, a professor of translational cancer at the University of Birmingham, described Greaves as one of the modern cancer biological circles. “Superstar”.
In such Greaves, the measures that protect children from infection are probably one of the causes of the most common cancers in children.
The Guardian reported that in the past 1950 and 1960s, ALL was fatal, and in today’s society, nearly 90% of the children could be cured – but the course was long and “toxic” and could have long-term consequences.
Greaves believes that there is a three cause for the onset of ALL. Some children have related mutations at birth, although these children have a potential risk of illness, but at this stage, as long as their immune system develops normally, they can be separated from the potential crisis.
In order to develop the immune system, child children must be exposed to the early challenges of benign bacteria or viruses in the first year of birth. Those who live in a clean and sterile environment which make the immune system unable to fully function, may have second genetic mutations when they later encounter a disease such as a cold or a flu. It makes it easy to suffer from cancer.
Greaves points out that the number of patients with ALL continues to grow at a rate of about 1% per year, and that, unlike most diseases, the growth of ALL is more common among people living in rich life, which is associated with type first diabetes, Hodge’s s lymphoma (Hodgkin ‘s lymphoma), multiple sclerosis (MS) and allergies. Similar。
ALL leukemia is rare in poor countries. (Source:pixabay)
In those poorest countries, families usually have many children, and the cross infection of the disease is common, but the proportion of the local ALL is very low or not – and only goidaga is an exception. They invest heavily in the medical system and reduce the average number of children from 7.2 to 2.3. Like those advanced countries, Costa Rica now has many patients suffering from Hodge’s lymphoma, type first diabetes or ALL.
Greaves therefore concludes that this phenomenon must be related to some aspects of modern life style. “Infectious diseases will follow the” poverty “. The problem is not infection, but the problem is lack of infection. “
Greaves, after integrating the evidence from colleagues in various fields of the world, published a paper in the Journal Nature Reviews Cancer, which also included an experiment on mice; in this experiment, mice were first modified to carry the first gene mutation, The researchers then made it live under sterile conditions and then developed cancer after being transferred to a dirty environment.
However, even with this inference, Greaves and other scientists must emphasize that any parent should not feel responsible for the cancer of the child at any point of view, because it is very normal for a baby to stay away from any source of infection. Greaves hopes that this research can promote the development of vaccines or drugs to prevent childhood leukemia.
(the source of the first map: pixabay)
- Bacteria help develop the immune system.